cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
نویسندگان
چکیده
منابع مشابه
The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel
Individuals vary extensively in the way they respond to disease but the genetic basis of this variation is not fully understood. We found substantial individual variation in resistance and tolerance to the fungal pathogen Metarhizium anisopliae Ma549 using the Drosophila melanogaster Genetic Reference Panel (DGRP). In addition, we found that host defense to Ma549 was correlated with defense to ...
متن کاملCis-regulatory variation is typically polyallelic in Drosophila.
Gene expression levels vary heritably, with approximately 25-35% of the loci affecting expression acting in cis. We characterized standing cis-regulatory variation among 16 wild-derived strains of Drosophila melanogaster. Our experiment's robust biological and technical replication enabled precise estimates of variation in allelic expression on a high-throughput SNP genotyping platform. We obse...
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We used 197 Drosophila melanogaster Genetic Reference Panel (DGRP) lines to perform a genome-wide association analysis for virgin female lifespan, using ~2M common single nucleotide polymorphisms (SNPs). We found considerable genetic variation in lifespan in the DGRP, with a broad-sense heritability of 0.413. There was little power to detect signals at a genome-wide level in single-SNP and gene...
متن کاملGenetic and epigenetic dissection of cis regulatory variation.
Divergence in gene expression is of interest because it generates molecular markers for phenotypic variation, potentially including the causes underlying this variation. Alteration of gene expression patterns can have a direct genetic (or epigenetic) basis in cis regulatory polymorphism or can be indirectly regulated by trans-acting factors. Expression mapping studies have begun to reveal the l...
متن کاملProposal to Sequence a Drosophila Genetic Reference Panel: A Community Resource for the Study of Genotypic and Phenotypic Variation
Overview: We propose the sequencing of a D. melanogaster genetic reference panel of 192 wild-type lines from a single natural population which have been inbred to homozygosity, and for which extensive information on complex trait phenotypes has been collected. This will create: (1) A community resource for association mapping of quantitative trait loci. Within this project we will demonstrate s...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2020
ISSN: 1474-760X
DOI: 10.1186/s13059-019-1912-z